alli® (orlistat 60mg capsules) is your smart edge for weight loss. It’s the only FDA-approved over-the-counter weight-loss aid.  It works by preventing about 25% of the fat you eat from getting absorbed. So for every 2 pounds you lose through diet and exercise, alli® can help you lose one more. alli® (orlistat 60mg capsules) is a weight loss aid for overweight adults, 18 years and older, when used along with a reduced-calorie and low-fat diet. Follow label directions.The active ingredient in alli® is orlistat, the most thoroughly studied weight loss drug in the world. Since its introduction in 1997, orlistat has been the subject of more than 100 clinical studies with some 30,000 patients. And in the real world, orlistat has been used by more than 50 million people.alli® should be taken with each meal containing 15 grams of fat or less. Do not take more than three capsules daily. In order to ensure adequate vitamin absorption, people taking alli® should also take a daily multivitamin at bedtime.You should contact your healthcare professional before starting a diet or an exercise regimen. alli® (orlistat 60mg capsules) is a weight loss aid for overweight adults, 18 years and older, when used along with a reduced-calorie and low-fat diet.